It is very hard to generalize it varies from company to company and division to division within the same company. But your work experience in a Fortune 500 company will look very impressive and good for your future career prospects.
i have worked with forture 500 company and also in small company.. Some the work what we do in Forture 500 company will be worst than the small companies.
As arun said it all depends what you are going to do ...