I think, with my layman understanding of this, that you would need to have the client install an application that registers a URL type for browsers. For example see:
http://ventrilo.com/setup.php#Web_Links Where clicking something like "ventrilo://www.myserver.com:3784/servername=MyServer" would run an application with that resource call.
Unless significant work went into making this interaction graceful, it strikes me as a very inelegant solution. I would suggest you look hard at what you're trying to do, and brainstorm more unified ways to approach the problem.