Well Lisps usually are dinamyc typed and like ruby, groovy and so on is slower than static typed langs like
java.
On the other hand data is immutables and it "create" new data in memory in each function call.
But for example Clojure use persistent data structure to optimize data geneation and you can attach metadata with type hints for optimize the code
But remember: "Premature optimization is the root of all evil"
Lisp is one of the references of all new languages from python to ruby, scala and of course clojure (which is a dialect of lisp like arc or scheme) and can be used in
any type of apps, including enterprise although it shines in ai apps (for example
this)